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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 39 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | SirT6 Rabbit Polyclonal Antibody detects endogenous levels of SirT6 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
SirT6 also known as Sirtuin 6, SIR2L6 is a member of the sirtuin family, consisting of NAD+-dependent deacetylases that play significant roles in cellular regulation. This 355 amino acid protein localizes primarily in the nucleus, functioning as a deacetylase for histone H3 lysine 9 (H3K9), modulating telomeric chromatin structure and contributing to DNA repair processes and telomere maintenance. SirT6 maintains genomic stability through regulation of cellular aging and longevity. SirT6 binds zinc as a cofactor and expresses in four isoforms due to alternative splicing, influencing functional diversity and regulatory mechanisms within cells. SirT6 interactions with various proteins involved in DNA repair and chromatin remodeling underscore significance in cellular health and disease prevention. |
| Product Image Gallery | |
 Western blot analysis of extracts on HL60, A549, Mouse heart cells, using SirT6 Rabbit Polyclonal Antibody (EAB13982) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 39 kDa; Observed band size: 39-45 kDa |
