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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 55 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | SLC7A5/LAT1 Rabbit Polyclonal Antibody detects endogenous levels of SLC7A5/LAT1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
SLC7A5 also known as CD98, LAT1 is a multipass-membrane protein responsible for sodium-independent, high-affinity transport of large neutral amino acids. SLC7A5 functions as a disulfide-linked heterodimer with the amino acid transport protein CD98. SLC7A5 is expressed predominantly in adult lung and liver but is also expressed in brain, thymus, retina, testis, placenta, bone marrow and fetal liver. In the retina, SLC7A5 localizes to the blood-retinal-barrier (BRB) and mediates L-leucine transport from the blood to the retina. The devastating effects on the brain caused by phenylketonuria are due to the increased levels of SLC7A5 on the blood-brain-barrier in response to high concentrations of phenylalanine in the blood. SLC7A5 accepts the amino-acid related anticancer agent melphalan and plays a significant role in cell proliferation, differentiation, and invasion in esophageal squamous cell carcinoma. |
| Product Image Gallery | |
 Western blot analysis of extracts on A549, K562 cells, using SLC7A5/LAT1 Rabbit Polyclonal Antibody (EAB13987) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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