www.ebiocell.com
| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IP, ELISA | 39 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IP=1:100-500 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | SORD Rabbit Polyclonal Antibody detects endogenous levels of SORD protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
SORD(Sorbitol dehydrogenase) also known as SORD1 is a 357 amino acid enzyme that belongs to the zinc-containing alcohol dehydrogenase. SORD plays a crucial role in the metabolism of polyols. SORD is predominantly expressed in the kidney and lens of the eye, where SORD catalyzes the zinc-dependent conversion of sorbitol and xylitol to their corresponding ketoses, utilizing NAD+ as an oxidizing agent. This enzymatic activity is essential for the proper functioning of the sorbitol pathway, which is involved in sugar production and cellular energy metabolism. Disruptions in SORD function can lead to an accumulation of sorbitol, contributing to diabetic complications such as cataracts and microvascular issues. |
| Product Image Gallery | |
 Western blot analysis of extracts on U2OS, A431 cells, using SORD Rabbit Polyclonal Antibody (EAB13997) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
|
