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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 53 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-TRβ1 (Ser142) Rabbit Polyclonal Antibody detects endogenous levels of TRβ1 protein only when phosphorylated at Ser142. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TRβ1 also known as TR beta 1, THRB is a member of the thyroid hormone nuclear receptor family, plays a crucial role in mediating the effects of thyroid hormones on gene expression, which is vital for regulating metabolic processes, growth, and development. TRβ1 is primarily located in the nucleus, where TRβ1 functions as a ligand-dependent transcription factor, binding to thyroid hormone response elements (TREs) to modulate the transcription of target genes. Nuclear localization of TRβ1 is essential because TRβ1 allows for direct interaction with DNA and other transcriptional machinery, thereby influencing cellular responses to thyroid hormones. TRβ1 can form heterodimers with retinoid X receptors, enhancing transcriptional activity and allowing for a more nuanced regulation of gene expression in response to thyroid hormone levels. |
| Product Image Gallery | |
 Western blot analysis of extracts on 293 cells treated with PMA, using Phospho-TRβ1 (Ser142) Rabbit Polyclonal Antibody (EAB14045) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
Predicted band size: 53 kDa; Observed band size: 45 kDa |
