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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, ELISA | 24 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | TIMP3 Rabbit Polyclonal Antibody detects endogenous levels of TIMP3 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TIMP3 is a member of the TIMP gene family. TIMP3 plays a crucial role in regulating extracellular matrix remodeling and inhibits various metalloproteinases, including collagenases and gelatinases, which are involved in tissue degradation and repair processes. This inhibition maintains tissue integrity and prevents excessive matrix degradation, which can lead to pathological conditions such as fibrosis and cancer metastasis. TIMP3 is unique among tissue inhibitors of metalloproteinases as the only member secreted and found in the nucleus, suggesting a potential role in regulating gene expression and cellular signaling pathways. TIMP3 expression is particularly important in tissues undergoing remodeling, such as during wound healing and tumor progression, where TIMP3 may influence cancer cell invasive potential. |
| Product Image Gallery | |
 Western blot analysis of extracts on HepG2, HuvEc cells, using TIMP3 Rabbit Polyclonal Antibody (EAB14043) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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