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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 50 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | TNFR1 Rabbit Polyclonal Antibody detects endogenous levels of TNFR1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TNFR1 also known as TNF-R1, TNFRSF1A is a member of the TNF receptor superfamily of proteins. TNFR1 plays a pivotal role in mediating the effects of tumor necrosis factor, a key cytokine involved in inflammation and apoptosis. TNFR1′s presence on diverse cell types allows for a wide range of biological responses, including cell survival, proliferation, and differentiation, making TNFR1 essential for maintaining immune homeostasis. TNFR1 interacts with several signaling proteins, including TRADD, FADD, and RIP, which are crucial for propagating apoptotic signals within the cell. TNFR1′s ability to initiate apoptosis through its "death domain" motif underscores TNFR1′s significance in regulating cell fate and highlights TNFR1′s potential as a therapeutic target in diseases characterized by dysregulated apoptosis, such as cancer and autoimmune disorders. |
| Product Image Gallery | |
 Western blot analysis of extracts on A549, Mouse lung cells, using TNFR1 Rabbit Polyclonal Antibody (EAB14052) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 50 kDa; Observed band size: 50-55 kDa  Immunohistochemical analysis of paraffin-embedded Human kidney tissue, using TNFR1 Rabbit Polyclonal Antibody (EAB14052) at 1:200 dilution.
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