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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 46 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | OPG Rabbit Polyclonal Antibody detects endogenous levels of OPG protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
OPG (Osteoprotegerin) also known as TNFRSF11B, OCIF is a member of the TNF-receptor superfamily. OPG plays a crucial role in bone metabolism, primarily by inhibiting osteoclastogenesis, which is essential for maintaining bone density and preventing excessive bone resorption. As a secreted glycoprotein and member of the tumor necrosis factor receptor family, OPG acts as a decoy receptor for osteoclast differentiation factor (also known as RANKL), thereby preventing its interaction with RANK on osteoclast progenitor cells. This inhibition is vital for regulating bone remodeling, as an imbalance in osteoclast activity can lead to conditions such as osteoporosis. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, 293 cells, using OPG Rabbit Polyclonal Antibody (EAB14054) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 46 kDa; Observed band size: 44-55 kDa  Immunohistochemistry of paraffin-embedded Human breast cancer tissue, using OPG Rabbit Polyclonal Antibody (EAB14054) at 1:200 dilution.
 Immunofluorescence analysis of Mouse heart tissue, using OPG Rabbit Polyclonal Antibody (EAB14054) at 1:200 dilution.
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