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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 25 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | TREM2 Rabbit Polyclonal Antibody detects endogenous levels of TREM2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TREM2(Triggering receptor expressed on myeloid cells 2) is a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. TREM2 plays a crucial role in the immune response, particularly in myeloid cells, where TREM2 acts as a receptor that, upon binding to its ligand, initiates signaling pathways promoting macrophage activation and survival. This function is vital for maintaining immune homeostasis and responding to inflammation, as dysregulation of TREM2 signaling has been implicated in neurodegenerative diseases, including Alzheimer′s disease. TREM2 is located on chromosome 6p21.1 and encodes a 230 amino acid protein that forms a signaling complex with DAP12, enhancing immune response through upregulation of chemokine receptors and promoting dendritic cell maturation. |
| Product Image Gallery | |
 Western blot analysis of extracts on DU145, Mouse brain cells, using TREM2 Rabbit Polyclonal Antibody (EAB14064) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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