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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB | 33 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | TREX1 Rabbit Polyclonal Antibody detects endogenous levels of TREX1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TREX1(Three prime repair exonuclease 1) also known as CRV, AGS1, AGS5, DRN3, HERNS, DNase III is a member of the exonuclease superfamily. TREX1 plays a significant role in DNA metabolism and repair. TREX1 is predominantly expressed in the spleen, liver, thymus, colon, heart, brain, and small intestine, where TREX-1 localizes to the nucleus and functions as a homodimer. TREX1 is an exonuclease that requires magnesium as a cofactor for activity, demonstrating a preference for double-stranded DNA and operating in the 3′-5′ direction to yield nucleoside 5′-phosphates. Notably, TREX1 interacts with the SET complex, an endoplasmic reticulum-associated complex, and is involved in granzyme A-mediated apoptosis, highlighting its importance in cellular processes. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, Raji, HL60 cells, using TREX1 Rabbit Polyclonal Antibody (EAB14065) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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