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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 130 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Hamartin/TSC1 Rabbit Polyclonal Antibody detects endogenous levels of Hamartin/TSC1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Hamartin also known as TSC1 is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. Hamartin plays a crucial role in the regulation of cell growth and proliferation, particularly through interaction with tuberin to form a cytoplasmic complex essential for proper functioning of the mTOR signaling pathway. This pathway is vital for cellular processes such as protein synthesis, autophagy, and metabolism, and dysregulation is implicated in various diseases, including cancer and tuberous sclerosis complex. Hamartin expression in most adult tissues, especially in the brain, heart, and kidney, highlights importance in maintaining tissue homeostasis and function. |
| Product Image Gallery | |
 Western blot analysis of extracts on NIH/3T3 cells, using Hamartin/TSC1 Rabbit Polyclonal Antibody (EAB14073) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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