www.ebiocell.com
| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, ELISA | 45 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | TXNIP Rabbit Polyclonal Antibody detects endogenous levels of TXNIP protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TXNIP also known as VDUP1 is a thioredoxin-binding protein that is a member of the alpha arrestin protein family. TXNIP plays a crucial role in cellular stress responses, being upregulated by 1,25(OH)2D3 in reaction to oxidative stress, ultraviolet radiation, and heat shock. TXNIP acts as a natural antagonist of thioredoxin, contributing to tumor suppression by inducing cell cycle arrest at the G0/G1 phase, which is vital for preventing uncontrolled cell proliferation. Additionally, TXNIP is essential for the expression of CD122 and the maturation of natural killer (NK) cells, although TXNIP has a minimal impact on T and B cell development. |
| Product Image Gallery | |
 Western blot analysis of extracts on Raw264.7, Mouse lung cells, using TXNIP Rabbit Polyclonal Antibody (EAB14080) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
|
