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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 78 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | UVRAG Rabbit Polyclonal Antibody detects endogenous levels of UVRAG protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
UVRAG (UV radiation resistance-associated gene) also known as p63, DHTX is a 699 amino acid cytoplasmic protein that plays a crucial role in cellular homeostasis by activating the BECN1/PI 3-kinase complex, essential for autophagy. Autophagy is vital for degrading cellular proteins in lysosomes, and dysregulation can lead to uncontrolled cell growth, contributing to various diseases, including cancer. Mutations in UVRAG have been linked to colon cancer, indicating a significant role in suppressing proliferation and tumorigenicity of human colon cancer cells. UVRAG has been shown to complement ultraviolet sensitivity of xeroderma pigmentosum group C cells, highlighting importance in DNA repair mechanisms. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, Mouse liver cells, using UVRAG Rabbit Polyclonal Antibody (EAB14090) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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