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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 38 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | XRCC4 Rabbit Polyclonal Antibody detects endogenous levels of XRCC4 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
XRCC4 plays a crucial role in the DNA repair process, specifically in the non-homologous end joining pathway, which is essential for repairing double-strand breaks in DNA. This function is vital for maintaining genomic stability, as unrepaired DNA breaks can lead to mutations, cancer, and cell death. XRCC4 acts as an accessory factor for DNA ligase IV, enhancing its ability to join DNA fragments with nicks or broken ends, thereby facilitating the repair process. Additionally, XRCC4 is involved in V(D)J recombination, a critical mechanism for generating diversity in immune responses. Deficiencies in XRCC4 or its interacting partners can result in severe immunodeficiency and increased susceptibility to cancer, highlighting the importance of this protein in both DNA repair and immune system functionality. |
| Product Image Gallery | |
 Western blot analysis of extracts on COLO205 cells, using XRCC4 Rabbit Polyclonal Antibody (EAB14646) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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