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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 34 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | GDF-15/Mic-1 Rabbit Polyclonal Antibody detects endogenous levels of GDF-15/Mic-1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
GDF-15 also known as PDF, MIC-1, PLAB, NAG-1, PTGF-β is a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. GDF-15 plays a crucial role in cellular responses to stress and inflammation. GDF-15 is synthesized intracellularly and secreted as a dimer linked by disulfide bonds, with highest expression in epithelial cells and macrophages, while maintaining wide distribution in adult tissues. GDF-15 is secreted into the cerebrospinal fluid from the choroid plexus in the brain, highlighting importance in central nervous system function. p53 tumor suppressor protein regulates GDF-15 gene expression, and in cultured cerebellar granule neurons, GDF-15 prevents cell death by activating the Akt pathway while inhibiting ERK signaling. This trophic factor promotes cell survival and differentiation in specific neuronal populations. |
| Product Image Gallery | |
 Western blot analysis of extracts on HepG2, 293 cells, using GDF-15/Mic-1 Rabbit Polyclonal Antibody (EAB14118) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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