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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 23 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | HAND2 Rabbit Polyclonal Antibody detects endogenous levels of HAND2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
HAND2 also known as dHAND is a member of the basic helix-loop-helix family of transcription factors. HAND2 plays a significant role in cardiac development, particularly in establishing left-right asymmetry in the heart. HAND2 is predominantly expressed on the right side of the looped heart tube and in the pulmonary ventricle, where HAND2 activates the transcription of essential genes such as Ufd1, which is involved in the ubiquitin-proteasome pathway, and Cdc45, a key player in DNA replication. Proper functioning of HAND2 is vital for the development of the heart′s structure, ensuring correct formation of heart chambers during cardiogenesis. HAND2 is expressed in sympathetic neurons and chromaffin cells throughout embryonic and fetal development, highlighting HAND2′s importance in neural crest development. |
| Product Image Gallery | |
 Western blot analysis of extracts on K562 cells, using HAND2 Rabbit Polyclonal Antibody (EAB14142) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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