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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 65 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | IL-1RAP Rabbit Polyclonal Antibody detects endogenous levels of IL-1RAP protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
IL-1RAP also known as IL-1RAcP is a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. IL-1RAP plays a crucial role in the immune response by acting as an accessory protein that associates with the type-1 IL-1 receptor (IL-1RI) to facilitate signal transduction upon binding of pro-inflammatory cytokines IL-1α and IL-1β. This interaction is vital for the activation of downstream signaling pathways, including the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), which is essential for mediating inflammatory responses. Additionally, IL-1RAP exists in two major isoforms: the membrane-bound form (mIL-1RAcP), which promotes signaling, and the soluble form (sIL-1RAcP), which can inhibit IL-1 signaling, highlighting IL-1RAP′s dual role in regulating inflammation. |
| Product Image Gallery | |
 Western blot analysis of extracts on HepG2 cells, using IL-1RAP Rabbit Polyclonal Antibody (EAB14184) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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