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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 53 | Human, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | IL-6R Rabbit Polyclonal Antibody detects endogenous levels of IL-6R protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
IL-6R also known as IL-6Rα, CD126 a subunit of the interleukin 6 (IL6) receptor complex. IL-6R plays a crucial role in the immune response by mediating the effects of interleukin-6 (IL-6), a cytokine involved in inflammation and immune response. Upon binding of IL-6 to IL-6R, a signaling complex forms with gp130, which is essential for IL-6 signal transduction. This interaction activates intracellular signaling pathways that influence cell survival, proliferation, and differentiation, highlighting IL-6R alpha′s importance in various pathological conditions, including autoimmune diseases and cancers. Additionally, soluble IL-6R, generated through proteolytic cleavage, can enhance IL-6 signaling in a paracrine manner, further emphasizing IL-6R′s significance in modulating immune responses. |
| Product Image Gallery | |
 Western blot analysis of extracts on AD293, 4T1 cells, using IL-6R Rabbit Polyclonal Antibody (EAB14192) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human spleen tissue, using IL-6R Rabbit Polyclonal Antibody (EAB14192) at 1:200 dilution.
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