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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, FC, ELISA | 17 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 FC=1:10-100 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | IL-17A Rabbit Polyclonal Antibody detects endogenous levels of IL-17A protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
IL-17A also known as IL-17, CTLA8 is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A plays a pivotal role in immune responses against pathogens. Structurally, IL-17A forms a homodimer consisting of two identical subunits linked by disulfide bonds, a configuration crucial for biological activity and interaction with IL-17 receptor (IL-17R) on target cells. This structural arrangement enables IL-17A to induce the expression of other cytokines and chemokines, amplifying inflammatory responses and contributing to host defense mechanisms. Dysregulation of IL-17 has been implicated in various autoimmune and inflammatory diseases, making IL-17A an important target for therapeutic research. |
| Product Image Gallery | |
 Western blot analysis of extracts on Raji, Jurkat cells, using IL-17A Rabbit Polyclonal Antibody (EAB14199) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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