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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 48 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | IRF-8 Rabbit Polyclonal Antibody detects endogenous levels of IRF-8 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
IRF-8 also known as ICSBP is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. IRF-8 plays a crucial role as a transcription factor in the regulation of immune responses, particularly in the signaling pathways mediated by interferon-gamma (IFN-γ) during the differentiation of dendritic cells and macrophages. IRF-8 physically interacts with TRAF6, a key adaptor protein that modulates Toll-like receptor (TLR) signaling, facilitating the cross-talk between IFN-γ and TLR pathways, which is essential for effective immune responses. IRF-8 has been shown to antagonize the oncogenic Bcr/Abl fusion protein by downregulating Bcl-2, highlighting a potential role in cancer biology. |
| Product Image Gallery | |
 Western blot analysis of extracts on THP-1 cells, using IRF-8 Rabbit Polyclonal Antibody (EAB14210) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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