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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 431 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | MLL1/KAT2A Rabbit Polyclonal Antibody detects endogenous levels of MLL1/KAT2A protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MLL1 also known as KAT2A is a transcriptional coactivator that plays a crucial role in regulating embryonal and hematopoietic development, making MLL1 essential for proper cellular differentiation and proliferation. MLL1 function is particularly significant in acute myeloid leukemia, where MLL1 gene undergoes translocation with other genes, leading to oncogenic fusion proteins that disrupt normal gene regulation. MLL1 protein is involved in transcriptional regulation of various target genes, influencing processes such as cell cycle progression and apoptosis. Given MLL1′s pivotal role in gene expression and development, MLL1 is a key focus in cancer research, particularly in understanding mechanisms underlying leukemia. |
| Product Image Gallery | |
 Immunohistochemical analysis of paraffin-embedded Human brain tissue, using MLL1/KAT2A Rabbit Polyclonal Antibody (EAB14227) at 1:200 dilution.
 Immunohistochemical analysis of paraffin-embedded Human lung tissue, using MLL1/KAT2A Rabbit Polyclonal Antibody (EAB14227) at 1:200 dilution.
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