| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, ELISA | 40 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Biglycan/BGN Rabbit Polyclonal Antibody detects endogenous levels of Biglycan/BGN protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Biglycan also known as PGS1, BGN is a member of the small leucine-rich proteoglycan (SLRP) family of proteins. Biglycan plays a crucial role in the extracellular matrix, influencing bone cell differentiation and proliferation. This protein is characterized by the presence of two chondroitin sulfate glucosaminoglycan chains attached near its amino terminus, distinguishing biglycan from decorin, which has only one. The structural composition of Biglycan contributes to the regulation of collagen synthesis and the response to transforming growth factor beta (TGFβ), both essential for maintaining bone integrity and homeostasis. Notably, specimens deficient in biglycan exhibit a reduced capacity to generate bone cell precursors, diminished collagen production, and increased apoptosis, highlighting biglycan′s importance in skeletal health. |
| Product Image Gallery | |
 Western blot analysis of extracts on Jurkat cells, using Biglycan/BGN Rabbit Polyclonal Antibody (EAB13697) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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