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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, ELISA | 522 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | LRP2/Megalin Rabbit Polyclonal Antibody detects endogenous levels of LRP2/Megalin protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
LRP2 also known as GP330, Megalin is a member of the low-density lipoprotein receptor gene family, which includes other receptors like LDLR, LRP, VLDLR, and ApoER2. LRP2 is primarily located on the apical membrane of epithelial cells, particularly in the proximal kidney tubules, intestine, and ependymal cells, where LRP2 plays a crucial role in the reabsorption of essential molecules, including vitamin B12. Proper localization of LRP2 is vital for mediating the uptake of various ligands, such as apolipoprotein J (also known as Clusterin), which is associated with the clearance of beta-amyloid peptides linked to Alzheimer′s disease. Additionally, LRP2 serves as an antigenic determinant in Heymann nephritis in rats, highlighting megalin′s significance in kidney function and disease. |
| Product Image Gallery | |
 Western blot analysis of extracts on Mouse lung cells, using LRP2/Megalin Rabbit Polyclonal Antibody (EAB14244) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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