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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 178 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | LRP5 Rabbit Polyclonal Antibody detects endogenous levels of LRP5 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
LRP5(LDL receptor related protein 5) is a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. LRP5 plays a crucial role as a Wnt coreceptor, facilitating the binding of Wnt ligands to their receptors and thereby regulating the canonical Wnt signaling pathway, which is essential for various biological processes, including cell proliferation, differentiation, and bone development. LRP5 is expressed in the tibia of rats in regions associated with bone remodeling, highlighting its importance in skeletal health. Mutations in LRP5 can lead to the autosomal recessive disorder osteoporosis-pseudoglioma syndrome (OPPG), underscoring LRP5′s significance in maintaining bone mass and integrity. |
| Product Image Gallery | |
 Western blot analysis of extracts on HepG2 cells, using LRP5 Rabbit Polyclonal Antibody (EAB14245) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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