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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, ELISA | 37 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | MC1-R Rabbit Polyclonal Antibody detects endogenous levels of MC1-R protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MC1-R(Melanocortin 1 receptor) is a G protein–coupled receptor predominantly expressed in melanocytes where it regulates melanin synthesis and pigment switching. Upon binding melanocortins such as α-MSH, MC1-R activates adenylyl cyclase and cAMP/PKA signaling, promoting MITF-dependent transcriptional programs that support melanogenesis, DNA damage responses, and oxidative stress resilience. Variation or altered activity of MC1R is associated with pigmentation phenotypes and is widely studied in the context of UV-response biology and melanocyte transformation. These properties make MC1-R a useful node for interrogating GPCR signaling, cAMP-driven transcription, and pigment cell homeostasis in human cellular models. |
| Product Image Gallery | |
 Western blot analysis of extracts on COLO205, HepG2 cells, using MC1-R Rabbit Polyclonal Antibody (EAB14256) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human tonsil tissue, using MC1-R Rabbit Polyclonal Antibody (EAB14256) at 1:100 dilution.
 Immunofluorescence analysis of LOVO cell, using MC1-R Rabbit Polyclonal Antibody (EAB14256) at 1:100 dilution.
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