www.ebiocell.com
| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 172 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | MRP1/ABCC1 Rabbit Polyclonal Antibody detects endogenous levels of MRP1/ABCC1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MRP1 also known as ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. MRP1 plays a crucial role in cellular detoxification and the efflux of a wide range of substrates, including drugs and endogenous compounds, thereby contributing to multidrug resistance in cancer cells. MRP1′s function is particularly important in the context of chemotherapy, as overexpression of MRP1 can lead to reduced drug accumulation within cancer cells, ultimately resulting in treatment failure. MRP1 is an integral membrane protein that is predominantly expressed in various tissues, including the brain, lungs, and testis, as well as in peripheral blood cells, highlighting MRP1′s significance in both normal physiology and pathological conditions. |
| Product Image Gallery | |
 Western blot analysis of extracts on HepG2, Mouse liver cells, using MRP1/ABCC1 Rabbit Polyclonal Antibody (EAB14280) at 1:2000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
|
