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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB | 116 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | NLRC4 Rabbit Polyclonal Antibody detects endogenous levels of NLRC4 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
NLRC4 also konwn as CARD12 is a member of the caspase recruitment domain-containing NLR family. NLRC4 is predominantly expressed in bone marrow, with lower expression levels in lymph nodes, placenta, spleen, and brain tissues, highlighting significance in immune responses and hematopoiesis. NLRC4 features a nucleotide-binding site domain specific for ATP/dATP, allowing engagement in critical interactions with other proteins, including self-association and interaction with ASC (apoptosis-associated speck-like protein containing a CARD), which promotes apoptosis and inflammatory signaling pathways. NLRC4′s ability to modulate these processes underscores potential as a target for therapeutic interventions in diseases characterized by dysregulated apoptosis and inflammation. |
| Product Image Gallery | |
 Western blot analysis of extracts on Raw264.7, MCF7, Mouse heart cells, using NLRC4 Rabbit Polyclonal Antibody (EAB14305) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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