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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB | 108 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | NOD1 Rabbit Polyclonal Antibody detects endogenous levels of NOD1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
NOD1 also known as CARD4, NLRC1 is a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. NOD1 plays a crucial role in the innate immune response by recognizing specific bacterial peptidoglycans, which is essential for initiating a proper immune reaction to infections. Structurally, NOD1 contains a caspase recruitment domain (CARD) and a nucleotide-binding domain, which are vital for function in signaling pathways that activate nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB). This activation leads to the expression of pro-inflammatory cytokines, thereby enhancing the immune response. Additionally, NOD1 interacts with the CARD-containing kinase RICK, facilitating the recruitment of downstream signaling molecules and promoting apoptosis through the activation of caspase-9. |
| Product Image Gallery | |
 Western blot analysis of extracts on 293T, THP-1 cells, using NOD1 Rabbit Polyclonal Antibody (EAB14307) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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