| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 17 | Human, Mouse |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | NPC2 Rabbit Polyclonal Antibody detects endogenous levels of NPC2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
NPC2(Niemann Pick C2) is a protein containing a lipid recognition domain. NPC2 protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. NPC2 plays a crucial role in regulating the lipid composition of sperm membranes during maturation in the epididymis. This function is vital for proper sperm development and fertility, as alterations in lipid composition can affect membrane fluidity and functionality. Mutations in NPC2 gene can lead to Niemann-Pick disease type C2, a severe hereditary condition characterized by defective lysosomal release of cholesterol, resulting in symptoms such as frontal lobe atrophy and other neurological impairments. |
| Product Image Gallery | |
 Western blot analysis of extracts on U2OS cells, using NPC2 Rabbit Polyclonal Antibody (EAB14315) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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