www.ebiocell.com
| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 34 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Fibrillarin Rabbit Polyclonal Antibody detects endogenous levels of Fibrillarin protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Fibrillarin is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. Fibrillarin is a crucial nonhistone protein predominantly located in the fibrillar region of the nucleolus, specifically within the dense fibrillar and fibrillar center regions. Fibrillarin′s localization is vital for ribosome biogenesis, playing a key role in processing ribosomal RNA (rRNA) transcripts. During the cell cycle, Fibrillarin serves as an early marker for nucleolus formation in telophase, highlighting Fibrillarin′s importance in cellular division and nucleolar reassembly. Fibrillarin′s structure features an RNA-binding domain and an RNP consensus sequence, facilitating interaction with U3 small nucleolar RNA, further underscoring Fibrillarin′s essential function in rRNA maturation. |
| Product Image Gallery | |
 Western blot analysis of extracts on U2OS, PC12, Mouse brain cells, using Fibrillarin Rabbit Polyclonal Antibody (EAB14386) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
|
