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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 53 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-p70 S6 kinase β (Ser423) Rabbit Polyclonal Antibody detects endogenous levels of p70 S6 kinase β only when phosphorylated at Ser423. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
p70 S6 kinase β also known as S6Kbeta, P70S6Kb, RPS6KB2 is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. p70 S6 kinase β plays a crucial role in regulating protein synthesis and cell growth, primarily by phosphorylating ribosomal protein S6, which is essential for translating mRNAs that encode proteins involved in cell cycle progression and metabolism. p70 S6 kinase β is activated in response to growth factors and is part of a signaling cascade that includes the ERK MAP kinase family, which is regulated by upstream kinases such as MEK. Precise regulation of p70 S6 kinase β is vital for maintaining cellular homeostasis and responding to external stimuli, making p70 S6 kinase β a significant target for research in cancer and metabolic disorders. |
| Product Image Gallery | |
 Western blot analysis of extracts on K562 cells treated with EGF, using Phospho-p70 S6 kinase β (Ser423) Rabbit Polyclonal Antibody (EAB14461) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
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