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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, ELISA | 80 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PDE4C Rabbit Polyclonal Antibody detects endogenous levels of PDE4C protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PDE4C is a member of the phosphodiesterase family. PDE4C plays a crucial role in the hydrolysis of cyclic adenosine monophosphate (cAMP) to 5′AMP, thereby regulating intracellular cAMP levels that are vital for various cellular processes, including signal transduction, inflammation, and neuronal signaling. PDE4 family is characterized by a unique upstream conserved region (UCR), and the human PDE4C gene, located on chromosome 19p13.1, produces several splice variants, including isoforms PDE4C1-7. Notably, the long isoforms of PDE4C contain both UCR1 and UCR2, which are essential for the dimerization of PDE4 isoforms, while the short isoforms possess only UCR2. This structural distinction influences the enzyme′s activity and regulatory mechanisms, making PDE4C a significant target for therapeutic interventions in conditions such as asthma, depression, and other inflammatory diseases. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, A549 cells, using PDE4C Rabbit Polyclonal Antibody (EAB14354) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue, using PDE4C Rabbit Polyclonal Antibody (EAB14354) at 1:200 dilution.
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