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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 48 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PAX8 Rabbit Polyclonal antibody detects endogenous levels of PAX8 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PAX8 is a member of the paired box (PAX) family of transcription factors. PAX8 plays a significant role in embryogenesis and differentiation of thyroid follicular cells, vital for proper thyroid hormone biosynthesis. PAX8 is predominantly expressed in developing and adult thyroid, developing secretory system and, to a lesser extent, adult kidney. PAX8 interacts with other transcription factors, such as TTF-1 and TTF-2, to regulate expression of key genes involved in thyroid function, including sodium iodide symporter (NIS), thyroid peroxidase (TPO), thyroglobulin (TG), and thyrotropin receptor (TSHR). Mutations in PAX8 can lead to thyroid dysgenesis, highlighting its importance in thyroid development and function. |
| Product Image Gallery | |
 Western blot analysis of extracts on HT29, Mouse lung cells, using PAX8 Rabbit Polyclonal antibody (EAB11863) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue, using PAX8 Rabbit Polyclonal antibody (EAB11863) at 1:1000 dilution.
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