| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 141 | Human, Mouse |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | BRIP1 Rabbit Polyclonal Antibody detects endogenous levels of BRIP1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
BRIP1 also known as BACH1 is ubiquitously expressed with highest levels in testis, an expression pattern similar to that of BRCA1. BRIP1 plays a crucial role in maintaining genomic stability by participating in DNA repair processes. Specifically, BRIP1 is essential for resolving secondary structures of guanine-rich DNA that can form during lagging-strand DNA synthesis, which is vital for preventing genomic instability that can lead to tumorigenesis. BRIP1 binds directly to the BRCT repeats of BRCA1, and this complex formation is critical for BRCA1′s function in DNA damage response. Phosphorylation of BRIP1 at Ser 990 is required for BRCA1 interaction, linking BRIP1′s activity to the DNA damage-induced checkpoint control during the G2 to M phase transition of the cell cycle. |
| Product Image Gallery | |
 Western blot analysis of extracts on MCF7, Jurkat cells, using BRIP1 Rabbit Polyclonal Antibody (EAB11284) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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