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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IP, IHC-P, IF/ICC, FC | 33 | Human, Mouse, Rat, Pig |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:1000-5000 IP=1:100-500 IHC-P=1:1000-5000 IF/ICC=1:100-500 FC=1:100-500 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PD-L1 Mouse Monoclonal Antibody detects endogenous levels of PD-L1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PD-L1 also known as CD274, B7-H1 is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. PD-L1 plays a significant role in immune regulation by interacting with the PD-1 receptor on T cells, thereby inhibiting T cell activation and promoting immune tolerance. This interaction is particularly important in cancer, as many tumors exploit the PD-1/PD-L1 pathway to evade immune detection, making Pdcd-1L1 a key target for immunotherapy. Structurally, Pdcd-1L1 features immunoglobulin V-like and C-like domains along with a 30 amino acid cytoplasmic tail, which is essential for signaling capabilities. |
| Product Image Gallery | |
 Western blot analysis of extracts on THP-1, HepG2, Raw264.7 cells, using PD-L1 Mouse Monoclonal Antibody (EAB21399) at 1:3000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
Predicted band size: 33 kDa; Observed band size: 40-50 kDa |
