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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 88 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | DPP4/CD26 Rabbit Polyclonal Antibody detects endogenous levels of DPP4/CD26 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CD26 also known as DPP4 is a membrane glycoprotein and serine exopeptidase that plays a crucial role in immune regulation by cleaving X-proline dipeptides from the N-terminus of polypeptides. CD26 is primarily located on the surface of T cells, where CD26 functions as a co-stimulatory molecule that enhances T cell activation and regulates chemokine activity. This localization is vital for the immune response, as CD26 interacts with various proteins, including CXCR4 and gp120, which are implicated in the pathophysiology of HIV infection. CD26′s interaction with adenosine deaminase on dendritic cells facilitates a costimulatory signal in the immunological synapse, promoting the production of proinflammatory cytokines such as interferon-gamma, tumor necrosis factor-alpha, and interleukin-6. The interaction between CD26 and caveolin-1 contributes to the up-regulation of CD86 on monocytes, which is essential for effective antigen-specific T cell activation. |
| Product Image Gallery | |
 Western blot analysis of extracts on 293T, NIH/3T3 cells, using DPP4/CD26 Rabbit Polyclonal Antibody (EAB11026) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 88 kDa; Observed band size: 105 kDa  Immunohistochemical analysis of paraffin-embedded Human kidney tissue, using DPP4/CD26 Rabbit Polyclonal Antibody (EAB11026) at 1:200 dilution.
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