| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, FC, ELISA | 26 | Human, Mouse |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:100-500 IF/ICC=1:100-500 FC=1:50-200 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Bcl-10 Mouse Monoclonal antibody detects endogenous levels of Bcl-10 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Bcl-10 also known as CIPER, c-CARMEN, mE10 was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. Bcl-10 plays a crucial role in immune signaling and was initially identified as a gene that is truncated or mutated in MALT B cell lymphomas and other tumor types. Bcl-10 structure features an N-terminal caspase recruitment domain (CARD), which is essential for function in activating the NFκB signaling pathway via a NIK-dependent mechanism. This activation is significant as NFκB is a key regulator of immune responses and cell survival, making Bcl-10 a vital component in the modulation of apoptosis and inflammation. Furthermore, Bcl-10 has been implicated in the processing of caspase-9 to its active dimer, highlighting importance in apoptotic signaling. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, MCF7, Jurkat, NIH/3T3 cells, using Bcl-10 Mouse Monoclonal antibody (EAB22205) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human breast carcinoma tissue, using Bcl-10 Mouse Monoclonal antibody (EAB22205) at 1:200 dilution.
 Immunohistochemical analysis of paraffin-embedded Human liver tissue, using Bcl-10 Mouse Monoclonal antibody (EAB22205) at 1:200 dilution.
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