www.ebiocell.com
| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IF/ICC | 287 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IF/ICC=1:100-500 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Piezo1 Rabbit Monoclonal Antibody detects endogenous levels of Piezo1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Piezo1 also known as FAM38A is a mechanically-activated ion channel that links mechanical forces to biological signals. Piezo1 plays a regulatory role in macrophage-mediated inflammatory diseases, atherosclerosis, and cancer metastasis. Piezo1 is a trimer with three blade-like propellers inserted within the lipid bilayer with a central ion channel that senses various mechanical forces such as membrane tension, shear stress, and cyclical pressure. The protein is engaged in a variety of essential biological processes, including vascular and lymphatic valve development, musculoskeletal function, and bone formation . The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, U14 cells, using Piezo1 Rabbit Monoclonal Antibody (EAB22514) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
|
