www.ebiocell.com
| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 55 | Human, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | GSDME Rabbit Polyclonal Antibody detects endogenous levels of GSDME protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
GSDME(Gasdermin E) also known as DFNA5 is a 496 amino acid protein that is expressed in cochlea tissue, as well as in placenta, brain, heart, liver, lung and pancreas. GSDME plays a crucial role in auditory function; mutations in the gene encoding GSDME are associated with non-syndromic sensorineural deafness autosomal dominant type 5, a condition that leads to hearing loss due to damage in the auditory pathways of the brain. GSDME is located on human chromosome 7, which contains over 1,000 genes and accounts for nearly 5% of the human genome. Notably, defects in other genes on chromosome 7 have been implicated in various genetic disorders, including Osteogenesis imperfecta and Williams-Beuren syndrome, highlighting the critical nature of this chromosomal region in human health. |
| Product Image Gallery | |
 Western blot analysis of extracts on HEK293, Rat stomach cells, using GSDME Rabbit Polyclonal Antibody (EAB11100) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
|
