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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 98 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | IRP1 Rabbit Polyclonal Antibody detects endogenous levels of IRP1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
IRP1 also known as IRP-1, ACO1 is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. IRP1 plays a crucial role in iron metabolism, which is vital for maintaining cellular homeostasis. IRP1 functions as a regulatory factor that modulates iron uptake and storage in response to cellular iron levels and stress signals. Specifically, IRP1 can bind to iron-responsive elements (IREs) in mRNA, thereby influencing the translation of proteins involved in iron transport and storage. This regulatory mechanism is essential because dysregulation of iron homeostasis can lead to various diseases, including anemia and neurodegenerative disorders. |
| Product Image Gallery | |
 Western blot analysis of extracts on Mouse kidney, Mouse liver cells, using IRP1 Rabbit Polyclonal Antibody (EAB11106) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemistry analysis of paraffin-embedded Human colorectal cancer tissue, using IRP1 Rabbit Polyclonal Antibody (EAB11106) at 1:100 dilution.
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