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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, ELISA | 140 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PRDM16 Mouse Monoclonal Antibody detects endogenous levels of PRDM16 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PRDM16 also known as MEL1, PFM13 is a crucial transcription factor localized in the nucleus, consisting of 1,276 amino acids that feature one SET domain and ten C2H2-type zinc fingers. This unique structure enables PRDM16 to interact with specific DNA sequences, thereby regulating gene expression essential for various cellular processes, including hematopoiesis and adipogenesis. PRDM16 plays a role in the pathogenesis of acute myeloid leukemia and myelodysplastic syndrome, where dysregulation can lead to malignancy. PRDM16 exists in three isoforms due to alternative splicing, which contributes to functional diversity and potential implications in cancer biology. |
| Product Image Gallery | |
 Western blot analysis of extracts on Jurkat, K562 cells, using PRDM16 Mouse Monoclonal Antibody (EAB22443) at 1:2000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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