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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 68 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | EWS Rabbit Polyclonal Antibody detects endogenous levels of EWS protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
EWS also known as EWSR1 is a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. EWS plays a significant role in gene regulation and cellular processes. Notably, EWS gene is often involved in chromosomal translocations that lead to the formation of fusion proteins with transcription factors, such as ATF-1, which are implicated in human neoplasias. In Ewing sarcoma, EWS protein is fused to the DNA-binding domain of ETS transcription factors, including Fli-1, Erg, ETV1, E1AF, and FEV, resulting in the EWS/Fli-1 chimeric protein. This fusion protein acts as a potent transcriptional activator, enhancing the expression of target genes and promoting cell transformation, which is critical for tumorigenesis. |
| Product Image Gallery | |
 Western blot analysis of extracts on HepG2, NIH/3T3, COLO205 cells, using EWS Rabbit Polyclonal Antibody (EAB11113) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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