| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG2a | Monoclonal | WB, IP, IHC-P, IF/ICC, ELISA | 94 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:1000-5000 IP=1:100-500 IHC-P=1:100-500 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | GCN5 Mouse Monoclonal Antibody detects endogenous levels of GCN5 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
GCN5 also known as KAT2A, GCN5L2 is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. GCN5 plays a critical role as a histone acetyltransferase, facilitating the acetylation of lysine residues on histone tails, which leads to chromatin remodeling and the regulation of gene transcription. This function is essential for various cellular processes including cell cycle progression, differentiation, and response to environmental signals. By acetylating histones, GCN5 enhances the accessibility of transcription factors to DNA, promoting active gene expression, whereas counterpart histone deacetylases like HDAC1 and HDAC2 are involved in transcriptional repression. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, NIH/3T3, SKOV3, MCF7 cells, using GCN5 Mouse Monoclonal Antibody (EAB22661) at 1:3000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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