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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG2a | Monoclonal | WB, IHC-P, IF/ICC, ELISA | 67 | Human, Mouse, Rat, Rabbit, Pig |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:5000-20000 IHC-P=1:500-2000 IF/ICC=1:100-500 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | GAD1 Mouse Monoclonal Antibody detects endogenous levels of GAD1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
GAD1 also known as GAD67, SCP is one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. GAD1 plays a crucial role in the synthesis of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain. GAD1 is essential for maintaining the balance of excitatory and inhibitory signals in the central nervous system, which is vital for normal brain function and preventing neurological disorders. Unlike GAD2, which is localized to synaptic vesicle membranes in nerve terminals and activated during increased demand for GABA, GAD1 is distributed throughout the cell and is responsible for the basal levels of GABA synthesis. Loss of GAD1 can lead to severe consequences, including lethality, highlighting GAD-67′s importance in neurotransmission. |
| Product Image Gallery | |
 Western blot analysis of extracts on Mouse brain, Rat brain, Rabbit brain, Pig brain cells, using GAD1 Mouse Monoclonal Antibody (EAB22667) at 1:20000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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