www.ebiocell.com
| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 71 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | MEKK3 Rabbit Polyclonal Antibody detects endogenous levels of MEKK3 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MEKK3(MEK kinase 3) also known as MAP3K3 is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. MEKK3 plays a crucial role in mitogen-activated protein (MAP) kinase signaling pathways, which are essential for cellular responses to various extracellular stimuli, including growth factors. Specifically, MEKK3 is involved in phosphorylation and activation of downstream MAP kinases, such as ERK, JNK, and p38, which are pivotal for regulating processes like cell proliferation, differentiation, and survival. Precise regulation of these pathways is vital for maintaining normal cellular functions and preventing diseases such as cancer, where aberrant signaling can lead to uncontrolled cell growth. |
| Product Image Gallery | |
 Western blot analysis of extracts on HepG2, Mouse brain cells, using MEKK3 Rabbit Polyclonal Antibody (EAB11702) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue, using MEKK3 Rabbit Polyclonal Antibody (EAB11702) at 1:200 dilution.
|
