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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG2b | Monoclonal | WB, ELISA | 42 | Human |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:5000-20000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | MVK Mouse Monoclonal Antibody detects endogenous levels of MVK protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MVK(Mevalonate kinase) is an early enzyme in isoprenoid and sterol synthesis. MVK plays a crucial role as an early enzyme in the biosynthesis of isoprenoids and sterols, catalyzing the ATP-dependent phosphorylation of mevalonic acid to produce mevalonate 5-phosphate. This reaction is vital because mevalonate serves as a key intermediate in the synthesis of cholesterol and other essential biomolecules, which are critical for cellular membrane integrity and signaling pathways. Deficiencies in MVK activity can lead to serious metabolic disorders, such as mevalonic aciduria and hyperimmunoglobulinemia D/periodic fever syndrome (HIDS), where the accumulation of mevalonic acid occurs due to the impaired conversion to 5-phosphomevalonic acid. |
| Product Image Gallery | |
 Western blot analysis of extracts on K562, Jurkat, HepG2 cells, using MVK Mouse Monoclonal Antibody (EAB22691) at 1:5000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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