| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, ELISA | 71 | Human |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | LILRB1/CD85j Mouse Monoclonal Antibody detects endogenous levels of LILRB1/CD85j protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
LILRB1 also known as CD85j, MIR7, ILT-2 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. LILRB1 plays a crucial role in immune regulation by binding to major histocompatibility complex (MHC) class I molecules, which inhibits the activation of natural killer (NK) and T cells, thereby preventing excessive immune responses. The presence of LILRB1 on immune cells, such as monocytes, B cells, and dendritic cells, is vital for maintaining immune homeostasis and tolerance, particularly in preventing autoimmunity and modulating responses to pathogens. Additionally, LILRB1′s interaction with B cell antigen receptor and histocompatibility leukocyte antigens (HLA)-DR can inhibit calcium mobilization in myeloid cells, further underscoring LILRB1′s importance in immune signaling pathways. |
