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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, FC, ELISA | 39 | Human |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 FC=1:10-100 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | P2Y12 Mouse Monoclonal Antibody detects endogenous levels of P2Y12 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
P2Y12 also known as P2RY12 is a member of the family of G-protein coupled receptors. P2Y12 is a Gi-coupled GPCR that senses extracellular ADP to suppress cAMP signaling and coordinate platelet activation, aggregation, and thrombus stabilization through downstream PI3K/AKT and integrin signaling. Beyond hemostasis, P2Y12 is a characteristic marker of homeostatic microglia and modulates chemotaxis, process motility, and neuroimmune surveillance in response to nucleotides. Altered P2RY12 activity or expression has been linked to abnormal platelet reactivity and to microglial state changes observed in neuroinflammatory and neurodegenerative contexts. |
| Product Image Gallery | |
 Western blot analysis of extracts on PC3, C6 cells, using P2Y12 Mouse Monoclonal Antibody (EAB21183) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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