| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | IHC-P, FC, ELISA | 39 | Human |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
IHC-P=1:100-500 FC=1:50-200 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | DNAM-1/CD226 Mouse Monoclonal Antibody detects endogenous levels of DNAM-1/CD226 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
DNAM-1 also known as CD226 is a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. DNAM-1 is predominantly expressed on T cells and natural killer (NK) cells, playing a vital role in the immune response by facilitating primary adhesion during cytotoxic T lymphocyte-mediated cytotoxicity. This adhesion is essential for the effective targeting and elimination of infected or malignant cells, highlighting DNAM-1′s importance in maintaining immune surveillance and response. DNAM-1′s interaction with ligands on target cells enhances the cytotoxic activity of T cells and NK cells, making DNAM-1 a significant player in the immune system′s ability to combat tumors and infections. |
| Product Image Gallery | |
 Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue, using DNAM-1/CD226 Mouse Monoclonal Antibody (EAB21190) at 1:200 dilution.
 Immunohistochemical analysis of paraffin-embedded Human kidney cancer tissue, using DNAM-1/CD226 Mouse Monoclonal Antibody (EAB21190) at 1:200 dilution.
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