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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 274 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-IGF-IIR (Ser2484) Rabbit Polyclonal Antibody detects endogenous levels of IGF-IIR protein only when phosphorylated at Ser2484. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
IGF-IIR also known as M6P-R, IGF2R is a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. IGF-IIR plays a significant role in cellular processes. IGF-IIR is primarily located in the cell membrane, where IGF-IIR functions as a receptor that binds glycoproteins through extracytoplasmic domains. This binding is essential for mediating the activation of transforming growth factor beta 1 (TGFβ1), which acts as a growth inhibitor, as well as for the degradation of insulin-like growth factor II (IGF-II) and the transport of lysosomal enzymes. IGF-IIR′s ability to form oligomeric complexes enhances affinity for lysosomal enzymes, thereby facilitating their transport and function. Unlike IGF-IR, IGF-IIR does not promote the signaling pathways associated with IGF-I or IGF-II, which are known for their mitogenic and cell survival effects, thus positioning IGF-IIR as a tumor suppressor. |
