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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 94 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-TrkC (Tyr516) Rabbit Polyclonal Antibody detects endogenous levels of TrkC protein only when phosphorylated at Tyr516. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TrkC also known as NTRK3 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkC plays a crucial role in the nervous system as a receptor for neurotrophin-3 (NT-3), which is essential for the survival and differentiation of neurons. TrkC is predominantly expressed in nervous tissue, and activation leads to phosphorylation of tyrosine residues, triggering downstream signaling pathways that promote neuronal growth and survival. Notably, TrkC undergoes alternative splicing, resulting in four isoforms, each with distinct structural features that may influence functional properties and interactions with NT-3. Understanding specific interactions and signaling mechanisms of TrkC is vital for elucidating its role in neurodevelopment and potential implications in neurodegenerative diseases. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela cells treated with Serum, using Phospho-TrkC (Tyr516) Rabbit Polyclonal Antibody (EAB11255) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
Predicted band size: 94 kDa; Observed band size: 160 kDa |
